Scientists at the University of British Columbia and BetaLogics have shown for the first time that Type 2 diabetes can be effectively treated with a combination of specially-cultured stem cells and conventional diabetes drugs.
Stem cells – generic cells that haven’t yet taken on specialized form and function – have recently been used by scientists at UBC and elsewhere to reverse Type 1 diabetes in mice. In Type 1 diabetes, which usually begins in childhood, the pancreas produces little or no insulin, the hormone that enables cells to metabolize sugar.
These new results, published today (2015-3-20) in Stem Cell Reports, hold much broader potential because Type 2 diabetes – which usually arises in adulthood, often stemming from poor diet, lack of exercise and obesity – accounts for more than 90 per cent of diabetes cases.
Timothy Kieffer, a professor in the department of cellular and physiological sciences, and scientists from BetaLogics, part of Janssen Research & Development, LLC, simulated Type 2 diabetes in mice by putting them on a high-fat, high-calorie diet for several weeks. Kieffer’s team then surgically implanted pancreatic-like cells that had been grown in the laboratory from human stem cells.
Mice that received a combination of the cells with one of three diabetes drugs became as “glucose tolerant” as the healthy mice, meaning they were able to keep their blood sugar in check, even after ingesting a sugary meal. In contrast, a group of mice with simulated Type 2 diabetes that received the drugs but not the transplants remained glucose-intolerant.
“Being able to reduce spikes in blood sugar levels is important because evidence suggests it’s those spikes that do a lot of the damage – increasing risks for blindness, heart attack, and kidney failure,” says Kieffer, a member of UBC’s Life Sciences Institute.
The combination therapy also produced an unexpected, but welcome result: the mice returned to a normal weight, the same weight as a healthy control group that had been reared on a low-fat diet.
“Their weight loss was intriguing, because some of the common diabetes therapies often lead to weight gain,” Kieffer said. “We need to do more studies to understand how the cell transplants lead to weight loss.”
The team is also investigating if higher doses of the cells – beyond the five million tested in this study – can achieve the same results without the need for additional drugs.
Hope from stem cells: U.S. and Canadian regulators have approved clinical trials of stem cell treatments for Type 1 diabetes; the first patient received a transplant in October. Perhaps the biggest hurdle will be preventing a person’s immune system from rejecting the transplanted stem cells.
Support: Support: This work was funded in part by Janssen R&D, LLC, the Canadian Institutes of Health Research (CIHR) Regenerative Medicine and Nanomedicine Initiative, the Stem Cell Network (SCN), the JDRF, and Stem Cell Technologies.
Source: University of British Columbia